Mouse Models for Alström

Fat Aussie Mouse used in Alström Research.

Mouse models for Alström Syndrome exhibit most of the characteristics seen in human patients with Alström Syndrome, including vision and hearing impairment and obesity.

• Research with Mouse Models

  • Marshall JD, Maffei P, Collin GB, Naggert JK (2011). Current Genomics 12 (3): 225-235.

  • Legry V, Van Rooyen DM, Lambert B, Sempoux C, Poekes L, Español-Suñer R, Molendi-Coste O, Horsmans Y, Farrell GC, Leclercq IA. Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin resistant high-fat diet fed foz/foz mice. Clin Sci (Lond). 2014 Apr 25. [Epub ahead of print]

  • Larter CZ, Yeh MM, Haigh WG, Van Rooyen DM, Brooling J, Heydet D, Nolan CJ, Teoh NC, Farrell GC. Dietary modification dampens liver inflammation and fibrosis in obesity-related fatty liver disease.

  • Obesity (Silver Spring). 2013 Jun; 21(6):1189-99. doi: 10.1002/oby.20123. Epub 2013 May 10. 

  • Larter CZ, Yeh MM, Van Rooyen DM, Brooling J, Ghatora K, Farrell GC.

  • Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis.

  • J Gastroenterol Hepatol. 2012 Feb;27(2):341-50. doi: 10.1111/j.1440-1746.2011.06939.x.

  • Collin GB, Cyr E, Bronson R, Marshall JD, Gifford EJ, Hicks W, Murray SA, Zheng QY, Smith RS, Nishina PM, Naggert JK. (2005):Alms1-disrupted mice recapitulate human Alström syndrome. Hum Mol Genet.14(16):2323-33.

  • Arsov T, Silva DG, O’Bryan MK, Sainsbury A, Lee NJ, Kennedy C, Manji SS, Nelms K, Liu C, Vinuesa CG, de Kretser DM, Goodnow CC, Petrovsky N (2006): Fat aussie–a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Mol Endocrinol. 20(7):1610-22.

  • Arsov T, Larter CZ, Nolan CJ, Petrovsky N, Goodnow CC, Teoh NC, Yeh MM, Farrell GC. (2006): Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem Biophys Res Commun. 342(4):1152-9.

• Need a Mouse for Your Research?

  The Jackson Laboratory, Bar Harbor, ME, USA currently has the Fat Aussie mouses used in Alström research. We encourage you to reach out to them.